Detalhe da pesquisa
1.
GPR84 regulates pulmonary inflammation by modulating neutrophil functions.
Acta Pharmacol Sin
; 44(8): 1665-1675, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37016043
2.
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages.
Acta Pharmacol Sin
; 43(8): 2042-2054, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34912006
3.
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.
Acta Pharmacol Sin
; 43(4): 1091-1099, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-34341512
4.
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue.
Acta Pharmacol Sin
; 42(6): 964-974, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32934347
5.
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models.
Acta Pharmacol Sin
; 42(4): 585-592, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32724176
6.
Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells.
Acta Pharmacol Sin
; 41(6): 813-824, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-31949294
7.
Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core.
Acta Pharmacol Sin
; 41(3): 293-302, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31316182
8.
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux.
Acta Pharmacol Sin
; 40(7): 908-918, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30560904
9.
Inhibition of KCNQ2/3 channels by HN38 and XE991 depends on the conformation of the outer vestibule.
Mol Pharmacol
; 2018 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30504241
10.
Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice.
Acta Pharmacol Sin
; 39(10): 1622-1632, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795358
11.
Discovery of a novel calcium-sensitive fluorescent probe for α-ketoglutarate.
Acta Pharmacol Sin
; 38(12): 1683-1690, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28713156
12.
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).
Org Biomol Chem
; 14(2): 747-751, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26584338
13.
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques.
Acta Pharmacol Sin
; 37(1): 105-10, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26725738
14.
Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels.
Proc Natl Acad Sci U S A
; 110(21): 8726-31, 2013 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23650395
15.
Azoxystrobin, a mitochondrial complex III Qo site inhibitor, exerts beneficial metabolic effects in vivo and in vitro.
Biochim Biophys Acta
; 1840(7): 2212-21, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726979
16.
Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.
Acta Pharmacol Sin
; 36(9): 1137-44, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26256403
17.
Total synthesis of aphadilactones A-D.
J Org Chem
; 79(13): 6294-301, 2014 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24959931
18.
Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors.
Bioorg Med Chem Lett
; 24(8): 1889-94, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24684845
19.
Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.
Org Biomol Chem
; 12(21): 3441-5, 2014 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752625
20.
Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy.
Acta Pharmacol Sin
; 35(11): 1463-72, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25283506